Hepatoprotective Effect of Calotropis procera in Isoniazid and Rifampicin Induced Hepatotoxicity
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چکیده
منابع مشابه
Hepatoprotective effect of tocopherol against isoniazid and rifampicin induced hepatotoxicity in albino rabbits.
Antitubercular drug induced hepatotoxicity is a major hurdle for an effective treatment of tuberculosis. The present study was undertaken to assess the hepatoprotective potential of tocopherol (50 mg/kg and 100 mg/kg, ip) and to compare it with cimetidine (120 mg/kg, ip). Hepatotoxicity was produced by giving isoniazid (INH, 50 mg/kg, po) and rifampicin (RMP, 100 mg/kg, po) combination to albin...
متن کاملEffect of Heptoplus on Isoniazid and Rifampicin Induced Hepatotoxicity in Liver Cell Lines
Objective: To evaluate the hepato protective role of Heptoplus (HP), a ployherbal formulation as a supplementary agent for the Isoniazid and Rifampicin induced oxidative stress and apoptosis in liver. Methods: Liver cell lines were divided in to five groups. Group I is control, group II is treated with 30ng/ml of INH+RIF, group III, IV and V are supplemented with 50, 100 and 200 ng/ml of HP. At...
متن کاملCalotropis procera Latex-Induced Inflammatory Hyperalgesia—Effect of Antiinflammatory Drugs
The milky white latex of plant Calotropis procera produces inflammation of the skin and mucous membranes on accidental exposure. It produces edema on local administration due to the release of histamine and prostaglandins and is associated with hyperalgesia. In the present study we have evaluated the antiedematous and analgesic activity of antiinflammatory drugs against inflammatory response in...
متن کاملEffect of cimetidine on hepatotoxicity induced by isoniazid-rifampicin combination in rabbits.
OBJECTIVE To evaluate the hepatoprotective potential of cimetidine in hepatotoxicity induced by isoniazid-rifampicin combination in albino rabbits. METHODS Six groups of six rabbits each were studied. Three groups received saline (control), isoniazid (50 mg/Kg/d) alone or isoniazid with rifampicin (100 mg/Kg/d) daily orally for 7 days. Other groups received intraperitoneal cimetidine (50 mg/K...
متن کاملCalotropis procera Root Extract\'s Anti-diabetic and Hepatoprotective Therapeutic Activity in Alloxan-Induced Pancreatic Toxicity in Wistar Rats
Background: Studies suggest that herbal remedies may serve as functional anti-diabetic agents. This study investigated the therapeutic role of Calotropis procera aqueous-methanol root extract in hyperglycaemic and hepatopathy disorders in Wistar rats after exposure to alloxan. This compound destroys pancreatic β-cells and produce diabetes in experimental animals. Methods: Spectrophotometric m...
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ژورنال
عنوان ژورنال: Pharmacognosy Journal
سال: 2014
ISSN: 0975-3575
DOI: 10.5530/pj.2014.5.3